Cerebrospinal Fluid Research
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Oral presentationMeasurement of capillary pulsations in the rat neocortex with two-photon laser scanning confocal microscopyJames P McAllister  , Mark E Wagshul, Shams Rashid and Jie Li Department of Neurosurgery, Primary Children's Medical Center, Salt Lake City, Utah, 84132, USA  author email corresponding author email
from 53rd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Belfast, UK. 24-27 June 2009 Cerebrospinal Fluid Research 2009,
6(Suppl 2):S10doi:10.1186/1743-8454-6-S2-S10
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| Published: |
27 November 2009 |
First paragraph (this article has no abstract)
Hydrocephalus is associated with increased pulsations in the cerebral aqueduct, as demonstrated by cine MRI, as well as increased pulse pressure, as demonstrated by invasive intracranial pressure monitoring. What has yet to be elucidated is the relationship between increased pulsations and the pathophysiology of hydrocephalus. Are increased pulsations an important component of the pathophysiology, or simply an artefact of decreased intracranial compliance? We have shown that under normal circumstances, the transmission of arterial pulsations into the cranium is minimized (the so-called Windkessel effect). In this paper, we sought to demonstrate this effect directly by measuring capillary pulsations with two-photon laser scanning confocal microscopy. | 
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