Cerebrospinal Fluid Research
Volume 5
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 Short paperHydrocephalus caused by conditional ablation of the Pten or beta-catenin geneAkihira Ohtoshi  Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, OH 43210, USA  author email corresponding author email
Cerebrospinal Fluid Research 2008,
5:16doi:10.1186/1743-8454-5-16
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18 October 2008 |
Abstract
To investigate the roles of Pten and β-Catenin in the midbrain, either the Pten gene or the β-catenin gene was conditionally ablated, using Dmbx1 (diencephalon/mesencephalon-expressed brain homeobox gene 1)-Cre mice. Homozygous disruption of the Pten or β-catenin gene in Dmbx1-expressing cells caused severe hydrocephalus and mortality during the postnatal period. Conditional deletion of Pten resulted in enlargement of midbrain structures. β-catenin conditional mutant mice showed malformation of the superior and inferior colliculi and stenosis of the midbrain aqueduct. These results demonstrate that both Pten and β-Catenin are essential for proper midbrain development, and provide the direct evidence that mutations of both Pten and β-catenin lead to hydrocephalus. | 
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