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This article is part of the supplement: 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida

Open AccessOral presentation

Pathogenesis of cerebral malformations in perinatal spina bifida aperta

Olga A de Wit1 email, WF den Dunnen2, KM Sollie3, OF Brouwer1 and DA Sival1,4

1Department of Pediatric Neurology, University of Groningen, University Medical Centre Groningen, the Netherlands

2Department of Pathology and Laboratory Medicine, University of Groningen, University Medical Centre Groningen, the Netherlands

3Department of Obstetrics, University of Groningen, University Medical Centre Groningen, the Netherlands

4Department of Pediatrics, University of Groningen, University Medical Centre Groningen, the Netherlands

author email corresponding author email

from 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Heidelberg, Germany. 27–30 June 2007

Cerebrospinal Fluid Research 2007, 4(Suppl 1):S9doi:10.1186/1743-8454-4-S1-S9

Published: 20 December 2007

First paragraph (this article has no abstract)

Spina bifida aperta (SBA) is associated with cerebral morbidity, such as hydrocephalus, Chiari II malformation and cortical dysplasia. Insight in the pathogenesis of these malformations is incomplete. In fetal SBA, such information may help to improve pre- and early postnatal treatment strategies. In perinatal SBA, we investigated the time of initiation of concurrent cerebral malformations.


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