Pathogenesis of cerebral malformations in perinatal spina bifida aperta

Olga A de Wit¹ , WF den Dunnen², KM Sollie³, OF Brouwer¹ and DA Sival¹^,4

¹Department of Pediatric Neurology, University of Groningen, University Medical Centre Groningen, the Netherlands

²Department of Pathology and Laboratory Medicine, University of Groningen, University Medical Centre Groningen, the Netherlands

³Department of Obstetrics, University of Groningen, University Medical Centre Groningen, the Netherlands

⁴Department of Pediatrics, University of Groningen, University Medical Centre Groningen, the Netherlands

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from 51^stAnnual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Heidelberg, Germany. 27–30 June 2007

Cerebrospinal Fluid Research 2007, 4(Suppl 1):S9doi:10.1186/1743-8454-4-S1-S9


Published:	20 December 2007

First paragraph (this article has no abstract)

Spina bifida aperta (SBA) is associated with cerebral morbidity, such as hydrocephalus, Chiari II malformation and cortical dysplasia. Insight in the pathogenesis of these malformations is incomplete. In fetal SBA, such information may help to improve pre- and early postnatal treatment strategies. In perinatal SBA, we investigated the time of initiation of concurrent cerebral malformations.