This article is part of the supplement: 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida

Oral presentation

Opposite changes in cerebellar vs. cortical blood brain barrier (BBB) expression in aged and hydrocephalic rats

Petra M Klinge¹ , Arthur Messier², Anna Heile¹, Mohsen Nouri¹, Conrad E Johanson², John A Duncan², Thomas Brinker¹ and Gerald D Silverberg²

¹Department of Neurosurgery, International Neuroscience Institute, Hanover 30625, Germany

²Department of Clinical Neuroscience, Brown University, Providence, RI 02903, USA

author email corresponding author email

from 51^st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Heidelberg, Germany. 27–30 June 2007

Cerebrospinal Fluid Research 2007, 4(Suppl 1):S4doi:10.1186/1743-8454-4-S1-S4

Published:	20 December 2007

First paragraph (this article has no abstract)

Little is known about the cerebellum in NPH. Studies show that neurotransmitter changes in the cerebellum are opposite to the cortex [1,2]. In Kaolin-induced hydrocephalus, increases of A-beta peptides at cortical and hippocampal microvessels were found [3]. Reciprocal changes in BBB receptors, LRP-1, which transports A-beta out of, and RAGE, which transports A-beta into the brain, indicated a defective clearance might be causal. We looked at LRP-1 and RAGE expression changes in the cerebellum vs. the cortex in hydrocephalic and aged rats.