This article is part of the supplement: 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida . Oral presentationOpposite changes in cerebellar vs. cortical blood brain barrier (BBB) expression in aged and hydrocephalic rats1 Department of Neurosurgery, International Neuroscience Institute, Hanover 30625, Germany 2 Department of Clinical Neuroscience, Brown University, Providence, RI 02903, USA
from 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Cerebrospinal Fluid Research 2007, 4(Suppl 1):S4doi:10.1186/1743-8454-4-S1-S4
First paragraph (this article has no abstract)Little is known about the cerebellum in NPH. Studies show that neurotransmitter changes in the cerebellum are opposite to the cortex [1,2]. In Kaolin-induced hydrocephalus, increases of A-beta peptides at cortical and hippocampal microvessels were found [3]. Reciprocal changes in BBB receptors, LRP-1, which transports A-beta out of, and RAGE, which transports A-beta into the brain, indicated a defective clearance might be causal. We looked at LRP-1 and RAGE expression changes in the cerebellum vs. the cortex in hydrocephalic and aged rats. |




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