This article is part of the supplement: 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida .

Oral presentation

Opposite changes in cerebellar vs. cortical blood brain barrier (BBB) expression in aged and hydrocephalic rats

Petra M Klinge¹ , Arthur Messier², Anna Heile¹, Mohsen Nouri¹, Conrad E Johanson², John A Duncan², Thomas Brinker¹ and Gerald D Silverberg²

¹  Department of Neurosurgery, International Neuroscience Institute, Hanover 30625, Germany

²  Department of Clinical Neuroscience, Brown University, Providence, RI 02903, USA

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from 51^st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Heidelberg, Germany. 27–30 June 2007

Cerebrospinal Fluid Research 2007, 4(Suppl 1):S4doi:10.1186/1743-8454-4-S1-S4

Published:	20 December 2007

First paragraph (this article has no abstract)

Little is known about the cerebellum in NPH. Studies show that neurotransmitter changes in the cerebellum are opposite to the cortex [1,2]. In Kaolin-induced hydrocephalus, increases of A-beta peptides at cortical and hippocampal microvessels were found [3]. Reciprocal changes in BBB receptors, LRP-1, which transports A-beta out of, and RAGE, which transports A-beta into the brain, indicated a defective clearance might be causal. We looked at LRP-1 and RAGE expression changes in the cerebellum vs. the cortex in hydrocephalic and aged rats.