This article is part of the supplement: 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida

Oral presentation

Does NPH equal ischemia?

Gerald Silverberg^1,2 , Conrad Johanson², John Duncan², Thomas Brinker³, Stephanie Slone², Arthur Messier², Sarah Soltman² and Petra Klinge³

¹Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA

²Department of Clinical Neuroscience, Brown University, Providence, RI 02903, USA

³Department of Neurosurgery, International Neuroscience Institute, Hanover 30625, Germany

author email corresponding author email

from 51^st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Heidelberg, Germany. 27–30 June 2007

Cerebrospinal Fluid Research 2007, 4(Suppl 1):S3doi:10.1186/1743-8454-4-S1-S3

Published:	20 December 2007

First paragraph (this article has no abstract)

It has been postulated that NPH equals pressure- and distortion-induced ischemia. Such a postulate fails to take into consideration the high co-incidence of AD and cerebrovascular disease (CVD) with NPH; as well as the observation that ischemia persists despite resolution of the elevated CSFP and ventriculomegaly [1,2]. We offer an alternate postulate, that NPH is a multi-factorial disease and that defective metabolite clearance, e.g., amyloid-beta peptides (Aβ) and Tau protein, via the CSF and across the blood-brain barrier (BBB), play a significant role in the dementia and ischemia of NPH.