This article is part of the supplement: 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida .

Oral presentation

Cerebrospinal fluid transport across the cribriform plate into extracranial lymphatics in rats: development and quantification

Miles Johnston , Gurjit Nagra, Lena Koh, Andrei Zakharov and Dianna Armstrong

Neuroscience Program, Department of Laboratory Medicine and Pathobiology, Room S-111, Research Building, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5

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from 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Cambridge, UK. 30 August – 2 September 2006

Cerebrospinal Fluid Research 2006, 3(Suppl 1):S9doi:10.1186/1743-8454-3-S1-S9

Published:	21 December 2006

First paragraph (this article has no abstract)

The notion that cerebrospinal fluid (CSF) absorption occurs mainly through the arachnoid granulations and villi is being challenged by studies that support a major role for the lymphatic circulation in CSF transport. An important pathway by which CSF is removed from the cranium is movement through the cribriform plate in association with the olfactory nerves. CSF is then absorbed directly into lymphatics located in the submucosa of the olfactory epithelium. In this report, (A) we determined the time during development at which the CSF compartment and extracranial lymphatic vessels connect anatomically in neonatal rats and (B) we investigated an indirect method to quantify this transport in adult rats.