This article is part of the supplement: 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida .

Oral presentation

The CSF of normal H-Tx rats promotes neuronal differentiation from neurospheres but CSF of hydrocephalic H-Tx rats does not

César González , Karin Vío, Rosa I Muñoz and Esteban M Rodríguez

Instituto de Histología y Patología, Universidad Austral de Chile, Valdivia, Chile

author email corresponding author email

from 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Cambridge, UK. 30 August – 2 September 2006

Cerebrospinal Fluid Research 2006, 3(Suppl 1):S10doi:10.1186/1743-8454-3-S1-S10

Published:	21 December 2006

First paragraph (this article has no abstract)

There is evidence that in both animal models and humans, hydrocephalus affects neuronal migration and maturation. In HTx rats evidence points to a critical role of CSF in maintaining the normal proliferation of the stem cells in the developing cortex. Furthermore, such an activity is affected by CSF of HTx rats with early-onset hydrocephalus. The source and nature of these signals in not known. However, the presence in the CSF of hydrocephalic HTx rats and hyh mice of abnormal forms of the proteins secreted by the subcommissural organ points to them as good candidates for conveying signals to the developing brain cortex. The present study was designed to investigate the effect of CSF on neurospheres obtained from neural stem cells of normal H-Tx rats.