This article is part of the supplement: 49th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida .

Oral presentation

Aging rat brain: a model for analyzing interactions among CSF dynamics, ventriculomegaly and the β-amyloid retention of alzheimer's disease

Conrad Johanson , Stephanie Flaherty, John Duncan, Edward Stopa and Gerald Silverberg

Department of Clinical Neuroscience Brown Medical School/RI Hospital 593 Eddy Street Providence, RI 02903 USA

author email corresponding author email

from 49th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Barcelona, Spain. 29 June – 2 July 2005

Cerebrospinal Fluid Research 2005, 2(Suppl 1):S6doi:10.1186/1743-8454-2-S1-S6

Published:	30 December 2005

First paragraph (this article has no abstract)

Age-associated disruptions in brain barrier systems (including choroid plexus) lead to multiple problems for CSF turnover and brain interstitial fluid composition. Age is a great risk factor for Alzheimer's disease (AD). We have presented evidence that beta-amyloid (Aβ) retention in AD is linked to decreased CSF turnover and reduced Aβ transport out of human brain. It is also known that CSF formation is reduced in aged rats (Preston et al.).