This article is part of the supplement: 49th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida .

Oral presentation

Progression and reversibility of gliosis due to hydrocephalus in the H-Tx rat

Alexander G Shanku^1,2 , Janet M Miller^1,2 and James P McAllister^1,2

¹  Departments of Neurosurgery and Physiology; Wayne State University School of Medicine

²  Department of Pediatric Neurosurgery, Children's Hospital of Michigan. Detroit, Michigan 48201

author email corresponding author email

from 49th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida
Barcelona, Spain. 29 June – 2 July 2005

Cerebrospinal Fluid Research 2005, 2(Suppl 1):S2doi:10.1186/1743-8454-2-S1-S2

Published:	30 December 2005

First paragraph (this article has no abstract)

Persistent gliosis, if present in shunt-dependent hydrocephalus, has the potential to alter the biomechanical properties of the brain, impair cerebral perfusion, and impede neuronal regeneration and plasticity. Determining the onset, progression, and reversibility of gliosis due to hydrocephalus is important in designing and implementing better clinical treatments for this disorder. Thus, gliosis was studied as the severity of hydrocephalus increased in five, twelve and twenty one day old untreated H-Tx rats with congenital hydrocephalus and control littermates. Previous clinical and experimental studies have suggested that gliosis may persist after shunting, but these findings have been based on relatively short post-shunt survival times.