Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species

doi:10.1186/1743-8454-1-2

Cerebrospinal Fluid Research

Volume 1

Viewing options:

Associated material:

Readers' comments (2)
PubMed record

Related literature:

Articles citing this article
on BioMed Central
on Google Scholar
on PubMed Central
Other articles by authors
on Google Scholar

Johnston M
Zakharov A
Papaiconomou C
Salmasi G
Armstrong D

on PubMed

Johnston M
Zakharov A
Papaiconomou C
Salmasi G
Armstrong D
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Comments(2)

Microfil marker in SAS
Scaling issues

Microfil marker in SAS

Martin Lubow (07 February 2005) Ohio State University

Important work. Well done.

Did the subarachnoid Microfil appear in arachnoid granulations and/or in dural wall tissues of cavernous sinus?

Competing interests

None declared

top

Scaling issues

Samuel Neff (17 February 2005) St. Christopher's Hospital for Children

This article confirms a popular explanation for the clinical observation that children with acute hydrocephalus (usually due to malfunction of an implanted CSF shunt) often have "swollen" eyes noted by their parents. I hope the authors are successful in additional human studies, so we can understand the range of variation in these channels.

An important clinical issue is the effect of brain size and size ratios on the application of these results. Many small mammals have brains that are comparable to (or within an order of magnitude of) the size of their eyes. Similarly, many large mammals have brains that are comparable in size to their peripheral olfactory systems. In humans, conversely, the brain is 1-2 orders of magnitude larger than either of these organs. So, the importance of these pathways in humans may be relatively small, not because they do not exist, but because there is so much more (CSF-producing) brain proportionately present.

Competing interests

None.

top

Comments(2)